منابع مشابه
-Cell Function Following Human Islet Transplantation for Type 1 Diabetes
Islet transplantation can provide metabolic stability for patients with type 1 diabetes; however, more than one donor pancreas is usually required to achieve insulin independence. To evaluate possible mechanistic defects underlying impaired graft function, we studied five subjects at 3 months and four subjects at 12 months following intraportal islet transplantation who had received comparable ...
متن کاملAutoantibody response to islet transplantation in type 1 diabetes.
Islet allotransplantation into patients with autoimmune type 1 diabetes represents a reexposure to autoantigen. Here, measurement of antibodies to GAD and IA-2 autoantigens before and after islet transplantation in 36 patients (33 receiving islet plus kidney grafts with cyclosporin and steroid-based immunosuppression, and 3 receiving solitary islet transplants with mycophenolate but cyclosporin...
متن کاملIslet Transplantation in Patients with Type 1 Diabetes Mellitus: Summary
Pancreatic islets are small clusters of endocrine cells in the pancreas that include insulinproducing beta cells. In type 1 diabetes—also known as juvenile or insulin-dependent diabetes—the body’s immune system specifically destroys the beta cells, resulting in a loss of insulin production. Pancreas transplants have been used as a way to restore insulin production, but require long-term treatme...
متن کاملIslet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes.
Islet transplantation can eliminate severe hypoglycemic episodes in patients with type 1 diabetes; however, whether intrahepatic islets respond appropriately to hypoglycemia after transplantation has not been fully studied. We evaluated six islet transplant recipients, six type 1 diabetic subjects, and seven nondiabetic control subjects using a stepped hyperinsulinemic-hypoglycemic clamp. Also,...
متن کاملIslet Transplantation in Type I Diabetes Mellitus
For most patients with type I diabetes, insulin therapy and glucose monitoring are sufficient to maintain glycemic control. However, hypoglycemia is a potentially lethal side effect of insulin treatment in patients who are glycemically labile or have hypoglycemia-associated autonomic failure [1]. For those patients, an alternative therapy is beta cell replacement via pancreas or islet transplan...
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ژورنال
عنوان ژورنال: Juntendo Medical Journal
سال: 2015
ISSN: 2187-9737,2188-2126
DOI: 10.14789/jmj.61.131